Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.51 |
| ▸ | DYRK1B | Q9Y463 | 4/20 | 0.50 |
| ▸ | CD38 | P28907 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.47 |
| ▸ | USP2 | O75604 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 7/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26174954 | 1.00 | DYRK1A (0.51) | DYRK1ADYRK1BCD38CYP1A2USP2 | |
| SCHEMBL30400346 | 0.90 | MAP3K11 (0.53) | DYRK1ADYRK1BCD38CYP1A2USP2 | |
| SCHEMBL26174993 | 0.90 | MAP3K11 (0.53) | DYRK1ADYRK1BCD38CYP1A2USP2 | |
| SCHEMBL26174951 | 0.88 | MAP4K1 (0.47) | DYRK1ADYRK1BMAP3K11 | |
| SCHEMBL30399949 | 0.88 | MAP4K1 (0.47) | DYRK1ADYRK1BMAP3K11 | |
| SCHEMBL26174952 | 0.88 | DYRK1A (0.53) | DYRK1ADYRK1BCYP1A2USP2CYP3A4 | |
| SCHEMBL30399196 | 0.88 | DYRK1A (0.53) | DYRK1ADYRK1BCYP1A2USP2CYP3A4 | |
| SCHEMBL30400811 | 0.86 | DYRK1A (0.47) | DYRK1ADYRK1BCD38CYP1A2USP2 | |
| SCHEMBL26175034 | 0.86 | DYRK1A (0.47) | DYRK1ADYRK1BCD38CYP1A2USP2 | |
| SCHEMBL30399937 | 0.86 | DYRK1A (0.52) | DYRK1ADYRK1BCD38CYP1A2IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4415817-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | claimed |
| WO-2023064349-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | claimed |