Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 7/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 7/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | INSR | P06213 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 5/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | MELK | Q14680 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2621741 | 1.00 | PDGFRB (0.46) | PDGFRBPDGFRAEGFRINSRLCK | |
| SCHEMBL2621739 | 0.93 | PDPK1 (0.42) | PDGFRBPDGFRAEGFRINSRLCK | |
| SCHEMBL2621738 | 0.87 | PDGFRB (0.42) | PDGFRBPDGFRAEGFRINSRLCK | |
| SCHEMBL2621744 | 0.86 | PDGFRB (0.43) | PDGFRBPDGFRAEGFRINSRLCK | |
| SCHEMBL2621745 | 0.86 | IRAK4 (0.47) | PDGFRBPDGFRAEGFRINSRLCK | |
| SCHEMBL2621743 | 0.85 | PDGFRB (0.45) | PDGFRBPDGFRAEGFRPDPK1 | |
| SCHEMBL2621731 | 0.84 | PDPK1 (0.45) | PDGFRBPDGFRAEGFRINSRLCK | |
| SCHEMBL2621756 | 0.84 | PDPK1 (0.47) | PDGFRBPDGFRAEGFRINSRLCK | |
| SCHEMBL2621748 | 0.84 | PDGFRB (0.59) | PDGFRBPDGFRAEGFRINSRLCK | |
| SCHEMBL2621765 | 0.82 | IRAK4 (0.44) | PDGFRBPDGFRAEGFRINSRLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4415817-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | disclosed |
| WO-2023064349-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | disclosed |