Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.48 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.46 |
| ▸ | CLK1 | P49759 | 2/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.46 |
| ▸ | PAK1 | Q13153 | 7/20 | 0.46 |
| ▸ | EIF2AK4 | Q9P2K8 | 4/20 | 0.46 |
| ▸ | PAK4 | O96013 | 2/20 | 0.45 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.45 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 3/20 | 0.43 |
| ▸ | GRK2 | P25098 | 1/20 | 0.43 |
| ▸ | GRK5 | P34947 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26175108 | 1.00 | EGFR (0.48) | EGFRERBB2ERBB4DYRK1ACLK1 | |
| SCHEMBL26175148 | 0.91 | FLT3 (0.48) | DYRK1ACLK1DYRK1BDYRK2MAPK7 | |
| SCHEMBL30398955 | 0.91 | FLT3 (0.48) | DYRK1ACLK1DYRK1BDYRK2MAPK7 | |
| SCHEMBL30399658 | 0.91 | DYRK1A (0.48) | DYRK1ACLK1DYRK1BPAK1PAK4 | |
| SCHEMBL26175109 | 0.91 | DYRK1A (0.48) | DYRK1ACLK1DYRK1BPAK1PAK4 | |
| SCHEMBL26175110 | 0.89 | DYRK1A (0.46) | DYRK1ACLK1DYRK1BPAK1PAK4 | |
| SCHEMBL30399049 | 0.89 | DYRK1A (0.46) | DYRK1ACLK1DYRK1BPAK1PAK4 | |
| SCHEMBL30399310 | 0.87 | DYRK1A (0.48) | DYRK1ACLK1DYRK1BPAK1PAK4 | |
| SCHEMBL26175076 | 0.87 | DYRK1A (0.48) | DYRK1ACLK1DYRK1BPAK1PAK4 | |
| SCHEMBL26175092 | 0.84 | PAK1 (0.46) | DYRK1ACLK1DYRK1BPAK1PAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4415817-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | claimed |
| WO-2023064349-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | claimed |