Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK7 | Q13164 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 12/20 | 0.48 |
| ▸ | CLK2 | P49760 | 5/20 | 0.48 |
| ▸ | CLK3 | P49761 | 5/20 | 0.48 |
| ▸ | GSK3B | P49841 | 6/20 | 0.48 |
| ▸ | OGA | O60502 | 1/20 | 0.47 |
| ▸ | CLK1 | P49759 | 3/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.47 |
| ▸ | MELK | Q14680 | 2/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26175149 | 1.00 | MAPK7 (0.49) | MAPK7DYRK1ACLK2CLK3GSK3B | |
| SCHEMBL26175148 | 0.91 | FLT3 (0.48) | MAPK7DYRK1ACLK2CLK3GSK3B | |
| SCHEMBL30398955 | 0.91 | FLT3 (0.48) | MAPK7DYRK1ACLK2CLK3GSK3B | |
| SCHEMBL26175109 | 0.90 | DYRK1A (0.48) | MAPK7DYRK1AGSK3BOGACLK1 | |
| SCHEMBL30399658 | 0.90 | DYRK1A (0.48) | MAPK7DYRK1AGSK3BOGACLK1 | |
| SCHEMBL26175115 | 0.88 | DYRK1A (0.48) | MAPK7DYRK1ACLK2CLK3GSK3B | |
| SCHEMBL30400698 | 0.88 | DYRK1A (0.48) | MAPK7DYRK1ACLK2CLK3GSK3B | |
| SCHEMBL30398632 | 0.88 | DYRK1A (0.48) | MAPK7DYRK1ACLK2CLK3GSK3B | |
| SCHEMBL30400661 | 0.88 | DYRK1A (0.48) | MAPK7DYRK1ACLK2CLK3GSK3B | |
| SCHEMBL26175150 | 0.88 | DYRK1A (0.48) | MAPK7DYRK1ACLK2CLK3GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4415817-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | claimed |
| WO-2023064349-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AS DYRK1A INHIBITORS | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | claimed |