Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20400834 | 1.00 | KDM4E (0.39) | KDM4ETSHRHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL20436650 | 0.91 | ADORA2A (0.41) | KDM4ETSHRHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL30402280 | 0.88 | LRRK2 (0.37) | ADORA2AADORA2BADORA1OXTRAVPR1A | |
| SCHEMBL20416700 | 0.88 | LRRK2 (0.37) | ADORA2AADORA2BADORA1OXTRAVPR1A | |
| SCHEMBL20421928 | 0.88 | LRRK2 (0.37) | ADORA2AADORA2BADORA1OXTRAVPR1A | |
| SCHEMBL20400534 | 0.87 | ADORA2A (0.49) | ADORA2AADORA2BADORA1 | |
| SCHEMBL30402211 | 0.87 | ADORA2A (0.49) | ADORA2AADORA2BADORA1 | |
| SCHEMBL20401228 | 0.85 | ADORA2A (0.39) | MAPTCASP1CASP7CYP1A2ADORA2A | |
| SCHEMBL20401313 | 0.85 | ADORA2A (0.39) | MAPTADORA2AADORA2BADORA1OXTR | |
| SCHEMBL30401305 | 0.85 | ADORA2A (0.39) | MAPTCASP1CASP7CYP1A2ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116768859-A | Azolopyrimidines for the treatment of cancer related disorders | 艾库斯生物科学有限公司 | 2023-09-19 | — | — | CN | disclosed |
| CN-110214012-B | Azolopyrimidines for the treatment of cancer related disorders | 艾库斯生物科学有限公司 | 2023-05-09 | — | — | CN | disclosed |