Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.46 |
| ▸ | TTK | P33981 | 9/20 | 0.44 |
| ▸ | PTK6 | Q13882 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24978344 | 0.92 | TTK (0.47) | MAPKAPK5TTKPTK6AURKBSYK | |
| SCHEMBL30385742 | 0.91 | MAPKAPK5 (0.48) | MAPKAPK5TTKPTK6MEN1NPC1 | |
| SCHEMBL25170256 | 0.91 | MAPKAPK5 (0.48) | MAPKAPK5TTKPTK6MEN1NPC1 | |
| SCHEMBL22123887 | 0.88 | TTK (0.47) | MAPKAPK5TTKPTK6MEN1NPC1 | |
| SCHEMBL30178059 | 0.86 | PTK6 (0.48) | MAPKAPK5TTKPTK6AURKB | |
| SCHEMBL22124274 | 0.86 | PTK6 (0.48) | MAPKAPK5TTKPTK6AURKB | |
| SCHEMBL22124581 | 0.85 | TTK (0.45) | MAPKAPK5TTKPTK6SYKBRAF | |
| SCHEMBL22123827 | 0.85 | PTK6 (0.44) | MAPKAPK5TTKPTK6AURKBAURKA | |
| SCHEMBL30187381 | 0.85 | PTK6 (0.44) | MAPKAPK5TTKPTK6AURKBAURKA | |
| SCHEMBL30349725 | 0.83 | MAPKAPK5 (0.55) | MAPKAPK5TTKPTK6AURKBSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3898630-B1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2023-05-10 | — | — | EP | disclosed |