Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 10/20 | 0.64 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.64 |
| ▸ | RET | P07949 | 8/20 | 0.51 |
| ▸ | KDR | P35968 | 7/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.49 |
| ▸ | MTOR | P42345 | 5/20 | 0.49 |
| ▸ | SRC | P12931 | 5/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.49 |
| ▸ | PRKDC | P78527 | 5/20 | 0.49 |
| ▸ | ABL1 | P00519 | 4/20 | 0.49 |
| ▸ | EGFR | P00533 | 3/20 | 0.49 |
| ▸ | HCK | P08631 | 3/20 | 0.49 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.41 |
| ▸ | CASK | O14936 | 1/20 | 0.41 |
| ▸ | GAK | O14976 | 1/20 | 0.41 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20552797 | 1.00 | PIK3CD (0.64) | PIK3CDPIK3CGRETKDRPIK3CA | |
| Trifluoroacetic Acid SCHEMBL29669807 | 0.92 | PIK3CD (0.56) | PIK3CDPIK3CGRETKDRPIK3CA | |
| Trifluoroacetic Acid SCHEMBL20553551 | 0.92 | PIK3CD (0.56) | PIK3CDPIK3CGRETKDRPIK3CA | |
| SCHEMBL21528027 | 0.86 | PIK3CD (0.60) | PIK3CDPIK3CGRETKDRPIK3CA | |
| SCHEMBL30405620 | 0.86 | PIK3CD (0.60) | PIK3CDPIK3CGRETKDRPIK3CA | |
| SCHEMBL20553552 | 0.82 | PIK3CD (0.45) | PIK3CDPIK3CGRETKDRPIK3CA | |
| SCHEMBL30404443 | 0.82 | RET (0.63) | PIK3CDPIK3CGRETKDRPIK3CA | |
| SCHEMBL21528193 | 0.82 | RET (0.63) | PIK3CDPIK3CGRETKDRPIK3CA | |
| SCHEMBL20552974 | 0.82 | RET (0.57) | PIK3CDPIK3CGRETKDRPIK3CA | |
| SCHEMBL30405191 | 0.82 | RET (0.57) | PIK3CDPIK3CGRETKDRPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4168002-A1 | METHODS FOR DELAYING, PREVENTING, AND TREATING ACQUIRED RESISTANCE TO RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2023-04-26 | — | — | EP | disclosed |