Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 6/20 | 0.39 |
| ▸ | EGFR | P00533 | 6/20 | 0.39 |
| ▸ | FAAH | O00519 | 4/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21528214 | 0.84 | BTK (0.42) | BTKEGFRPIK3CGRETPIK3CD | |
| SCHEMBL31186246 | 0.84 | BTK (0.42) | BTKEGFRPIK3CGRETPIK3CD | |
| SCHEMBL23150460 | 0.82 | BTK (0.45) | BTKEGFRPIK3CGRETPIK3CD | |
| SCHEMBL30405181 | 0.82 | FGFR4 (0.41) | BTKEGFRRETMTORHDAC1 | |
| SCHEMBL25678064 | 0.76 | PIK3CG (0.48) | BTKPIK3CGRETPIK3CDJAK2 | |
| SCHEMBL29172463 | 0.76 | BTK (0.43) | BTKEGFRPIK3CGRETPIK3CD | |
| SCHEMBL29867706 | 0.75 | PIK3CD (0.39) | BTKEGFRPIK3CGPIK3CDJAK2 | |
| SCHEMBL20553300 | 0.74 | RET (0.44) | RETMTORHDAC1JAK2 | |
| SCHEMBL30405312 | 0.74 | RET (0.44) | RETMTORHDAC1JAK2 | |
| SCHEMBL23251838 | 0.73 | SRC (0.38) | BTKEGFRPIK3CGRETPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4168002-A1 | METHODS FOR DELAYING, PREVENTING, AND TREATING ACQUIRED RESISTANCE TO RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2023-04-26 | — | — | EP | disclosed |