Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 9/20 | 0.52 |
| ▸ | MTOR | P42345 | 8/20 | 0.52 |
| ▸ | PRKDC | P78527 | 8/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.52 |
| ▸ | SRC | P12931 | 5/20 | 0.52 |
| ▸ | ABL1 | P00519 | 4/20 | 0.52 |
| ▸ | EGFR | P00533 | 3/20 | 0.52 |
| ▸ | HCK | P08631 | 3/20 | 0.52 |
| ▸ | KDR | P35968 | 3/20 | 0.52 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20553545 | 1.00 | PIK3CD (0.52) | PIK3CDMTORPRKDCPIK3CAPIK3CB | |
| Trifluoroacetic Acid SCHEMBL20553336 | 0.91 | MTOR (0.49) | PIK3CDMTORPRKDCPIK3CAPIK3CB | |
| Trifluoroacetic Acid SCHEMBL29669762 | 0.91 | MTOR (0.49) | PIK3CDMTORPRKDCPIK3CAPIK3CB | |
| SCHEMBL25678139 | 0.91 | MTOR (0.49) | PIK3CDMTORPRKDCPIK3CAPIK3CB | |
| SCHEMBL23157775 | 0.81 | ABL1 (0.52) | PIK3CDMTORPRKDCPIK3CAPIK3CB | |
| SCHEMBL30353302 | 0.80 | MTOR (0.54) | PIK3CDMTORPRKDCPIK3CAPIK3CB | |
| SCHEMBL20552603 | 0.80 | MTOR (0.74) | PIK3CDMTORPRKDCPIK3CAPIK3CB | |
| SCHEMBL30381095 | 0.80 | MTOR (0.74) | PIK3CDMTORPRKDCPIK3CAPIK3CB | |
| SCHEMBL29677976 | 0.78 | SRC (0.65) | PIK3CDMTORPRKDCPIK3CAPIK3CB | |
| SCHEMBL7901661 | 0.77 | SRC (0.66) | PIK3CDMTORPRKDCPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4168002-A1 | METHODS FOR DELAYING, PREVENTING, AND TREATING ACQUIRED RESISTANCE TO RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2023-04-26 | — | — | EP | disclosed |