Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 19/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.61 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.59 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.59 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.59 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.59 |
| ▸ | ABL1 | P00519 | 2/20 | 0.59 |
| ▸ | PRKDC | P78527 | 4/20 | 0.58 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.58 |
| ▸ | RICTOR | Q6R327 | 2/20 | 0.51 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.51 |
| ▸ | MAPKAP1 | Q9BPZ7 | 2/20 | 0.51 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.51 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30405407 | 1.00 | MTOR (0.61) | MTORHDAC1PIK3CDPIK3CAPIK3CG | |
| SCHEMBL20553616 | 1.00 | MTOR (0.61) | MTORHDAC1PIK3CDPIK3CAPIK3CG | |
| Hydrochloric Acid SCHEMBL27225374 | 0.99 | MTOR (0.60) | MTORHDAC1PIK3CDPIK3CAPIK3CG | |
| Hydrochloric Acid SCHEMBL29867328 | 0.99 | MTOR (0.60) | MTORHDAC1PIK3CDPIK3CAPIK3CG | |
| Trifluoroacetic Acid SCHEMBL29669777 | 0.93 | MTOR (0.59) | MTORHDAC1PIK3CDPIK3CAPIK3CG | |
| Trifluoroacetic Acid SCHEMBL20553079 | 0.93 | MTOR (0.59) | MTORHDAC1PIK3CDPIK3CAPIK3CG | |
| SCHEMBL21528205 | 0.90 | MTOR (0.49) | MTORHDAC1PIK3CDPIK3CAPIK3CG | |
| SCHEMBL30405245 | 0.90 | MTOR (0.49) | MTORHDAC1PIK3CDPIK3CAPIK3CG | |
| SCHEMBL24519411 | 0.85 | MTOR (0.60) | MTORHDAC1PIK3CDPIK3CAPIK3CG | |
| SCHEMBL21527979 | 0.84 | MTOR (0.57) | MTORHDAC1PIK3CDPIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118978535-A | C40-, C28-and C32-linked rapamycin analogues as mTOR inhibitors | 锐新医药公司 | 2024-11-19 | — | — | CN | disclosed |
| CN-118894869-A | C40-, C28-and C32-linked rapamycin analogues as mTOR inhibitors | 锐新医药公司 | 2024-11-05 | — | — | CN | disclosed |
| CN-112771054-B | C40-, C28-and C32-linked rapamycin analogues as mTOR inhibitors | 锐新医药公司 | 2024-08-16 | — | — | CN | disclosed |
| EP-4168002-A1 | METHODS FOR DELAYING, PREVENTING, AND TREATING ACQUIRED RESISTANCE TO RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2023-04-26 | — | — | EP | disclosed |