Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 1.00 |
| ▸ | HSP90AB1 | P08238 | 8/20 | 0.60 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21527992 | 0.89 | MAPT (0.81) | MAPTHSP90AB1GPR119LMNA | |
| SCHEMBL30363533 | 0.89 | MAPT (0.81) | MAPTHSP90AB1GPR119LMNA | |
| SCHEMBL21528007 | 0.87 | MAPT (0.77) | MAPTHSP90AB1 | |
| SCHEMBL31046962 | 0.87 | MAPT (0.77) | MAPTHSP90AB1 | |
| SCHEMBL1017921 | 0.87 | MAPT (0.77) | MAPTHSP90AB1SMN1; SMN2 | |
| SCHEMBL30405552 | 0.86 | MAPT (0.75) | MAPTHSP90AB1GPR119LMNATP53 | |
| SCHEMBL21528138 | 0.85 | MAPT (0.74) | MAPTHSP90AB1GPR119LMNATP53 | |
| SCHEMBL30805644 | 0.85 | MAPT (0.74) | MAPTHSP90AB1GPR119LMNATP53 | |
| SCHEMBL4074301 | 0.85 | MAPT (0.73) | MAPTHSP90AB1GPR119 | |
| SCHEMBL21528035 | 0.84 | MAPT (0.72) | MAPTHSP90AB1LMNATP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4168002-A1 | METHODS FOR DELAYING, PREVENTING, AND TREATING ACQUIRED RESISTANCE TO RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2023-04-26 | — | — | EP | disclosed |