Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 6/20 | 0.43 |
| ▸ | SRC | P12931 | 4/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.41 |
| ▸ | MTOR | P42345 | 3/20 | 0.41 |
| ▸ | PTK6 | Q13882 | 6/20 | 0.40 |
| ▸ | FYN | P06241 | 2/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | LYN | P07948 | 1/20 | 0.40 |
| ▸ | HCK | P08631 | 1/20 | 0.40 |
| ▸ | FRK | P42685 | 1/20 | 0.40 |
| ▸ | BLK | P51451 | 1/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | RET | P07949 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20553647 | 1.00 | ABL1 (0.43) | ABL1SRCHDAC1MTORPTK6 | |
| SCHEMBL23150480 | 0.94 | ABL1 (0.41) | ABL1SRCHDAC1MTORPTK6 | |
| SCHEMBL20553041 | 0.91 | ABL1 (0.48) | ABL1SRCHDAC1MTORPTK6 | |
| SCHEMBL25678085 | 0.90 | MTOR (0.42) | ABL1SRCHDAC1MTORPTK6 | |
| SCHEMBL25678083 | 0.90 | MTOR (0.42) | ABL1SRCHDAC1MTORPTK6 | |
| SCHEMBL19294576 | 0.86 | ABL1 (0.43) | ABL1SRCHDAC1MTORPTK6 | |
| SCHEMBL23150484 | 0.85 | ABL1 (0.47) | ABL1SRCHDAC1MTORPTK6 | |
| SCHEMBL23987945 | 0.81 | ABL1 (0.46) | ABL1SRCHDAC1MTORPTK6 | |
| SCHEMBL25678086 | 0.81 | ABL1 (0.46) | ABL1SRCHDAC1MTORPTK6 | |
| SCHEMBL20553605 | 0.81 | FGFR1 (0.45) | ABL1SRCHDAC1MTORPTK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4168002-A1 | METHODS FOR DELAYING, PREVENTING, AND TREATING ACQUIRED RESISTANCE TO RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2023-04-26 | — | — | EP | disclosed |