Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | TEK | Q02763 | 8/20 | 0.43 |
| ▸ | KDR | P35968 | 6/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24215771 | 1.00 | HDAC6 (0.53) | HDAC6HDAC3HDAC1HDAC2CYP19A1 | |
| SCHEMBL25351360 | 0.94 | HDAC6 (0.52) | HDAC6FLT3 | |
| SCHEMBL25993072 | 0.92 | HDAC6 (0.53) | HDAC6HDAC1TEKKDREPHB4 | |
| SCHEMBL25353042 | 0.92 | HDAC6 (0.53) | HDAC6HDAC1CYP19A1TEKKDR | |
| SCHEMBL24216754 | 0.91 | HDAC6 (0.61) | HDAC6HDAC3HDAC1HDAC2CYP19A1 | |
| SCHEMBL25352054 | 0.91 | HDAC6 (0.50) | HDAC6CYP19A1TEKKDREPHB4 | |
| SCHEMBL25352463 | 0.90 | HDAC6 (0.49) | HDAC6HDAC3HDAC1HDAC2CYP19A1 | |
| SCHEMBL25347988 | 0.90 | HDAC6 (0.51) | HDAC6HDAC1CYP19A1TEKKDR | |
| SCHEMBL25351712 | 0.89 | HDAC6 (0.61) | HDAC6HDAC3HDAC1HDAC2CYP19A1 | |
| SCHEMBL25351609 | 0.89 | HDAC6 (0.53) | HDAC6HDAC3HDAC1HDAC2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4185586-A1 | NOVEL COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | Chong Kun Dang Pharmaceutical Corp. (KR) | 2023-05-31 | — | — | EP | disclosed |
| CN-116133658-A | Novel compounds as inhibitors of histone deacetylase 6 and pharmaceutical compositions comprising the same | 株式会社 钟根堂 | 2023-05-16 | — | — | CN | disclosed |