Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 15/20 | 0.41 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.38 |
| ▸ | TEK | Q02763 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24216106 | 1.00 | HDAC6 (0.41) | HDAC6ATRHDAC1KDREPHB4 | |
| SCHEMBL25350719 | 0.91 | HDAC6 (0.45) | HDAC6ATRHDAC1 | |
| SCHEMBL30409824 | 0.88 | HDAC6 (0.39) | HDAC6HDAC1 | |
| SCHEMBL30408447 | 0.88 | HDAC6 (0.43) | HDAC6ATRKDREPHB4TEK | |
| SCHEMBL25348318 | 0.88 | HDAC6 (0.39) | HDAC6HDAC1 | |
| SCHEMBL25351353 | 0.88 | HDAC1 (0.42) | HDAC6HDAC1 | |
| SCHEMBL30409419 | 0.87 | HDAC6 (0.39) | HDAC6HDAC1KDREPHB4TEK | |
| SCHEMBL25351907 | 0.87 | HDAC6 (0.39) | HDAC6HDAC1KDREPHB4TEK | |
| SCHEMBL24215842 | 0.86 | HDAC6 (0.53) | HDAC6HDAC1 | |
| SCHEMBL30409045 | 0.86 | HDAC6 (0.53) | HDAC6HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4185586-A1 | NOVEL COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | Chong Kun Dang Pharmaceutical Corp. (KR) | 2023-05-31 | — | — | EP | disclosed |
| CN-116133658-A | Novel compounds as inhibitors of histone deacetylase 6 and pharmaceutical compositions comprising the same | 株式会社 钟根堂 | 2023-05-16 | — | — | CN | disclosed |