Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 17/20 | 0.48 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.40 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25200401 | 1.00 | MAP4K1 (0.48) | MAP4K1TNK2MAP4K3LRRK2 | |
| SCHEMBL25226508 | 0.93 | MAP4K1 (0.47) | MAP4K1TNK2MAP4K3LRRK2 | |
| SCHEMBL30412925 | 0.93 | MAP4K1 (0.47) | MAP4K1TNK2MAP4K3LRRK2 | |
| Hydrochloric Acid SCHEMBL30412709 | 0.92 | MAP4K1 (0.46) | MAP4K1TNK2MAP4K3LRRK2 | |
| Hydrochloric Acid SCHEMBL25230570 | 0.92 | MAP4K1 (0.46) | MAP4K1TNK2MAP4K3LRRK2 | |
| SCHEMBL30412433 | 0.92 | MAP4K1 (0.48) | MAP4K1 | |
| SCHEMBL25226866 | 0.92 | MAP4K1 (0.48) | MAP4K1 | |
| SCHEMBL25200206 | 0.91 | LRRK2 (0.42) | MAP4K1LRRK2 | |
| SCHEMBL30410883 | 0.91 | LRRK2 (0.42) | MAP4K1LRRK2 | |
| SCHEMBL25217872 | 0.89 | LRRK2 (0.42) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4433059-A1 | THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF | Erasca, Inc. (US) | 2024-09-25 | — | — | EP | disclosed |
| WO-2023215494-A1 | THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF | ERASCA, INC. (US) | 2023-11-09 | — | — | WO | disclosed |
| WO-2023087027-A1 | THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF | ERASCA, INC. (US) | 2023-05-19 | — | — | WO | disclosed |