Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 7/20 | 0.43 |
| ▸ | TYRO3 | Q06418 | 7/20 | 0.43 |
| ▸ | AXL | P30530 | 5/20 | 0.43 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 6/20 | 0.42 |
| ▸ | FLT3 | P36888 | 6/20 | 0.42 |
| ▸ | KIT | P10721 | 3/20 | 0.42 |
| ▸ | ESR1 | P03372 | 2/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25204972 | 1.00 | MERTK (0.43) | MERTKTYRO3AXLMAP4K1EGFR | |
| SCHEMBL30411174 | 1.00 | MERTK (0.43) | MERTKTYRO3AXLMAP4K1EGFR | |
| SCHEMBL25205416 | 1.00 | MERTK (0.43) | MERTKTYRO3AXLMAP4K1EGFR | |
| SCHEMBL30411785 | 0.94 | LRRK2 (0.42) | MERTKTYRO3AXLMAP4K1CHEK1 | |
| SCHEMBL25205942 | 0.94 | LRRK2 (0.42) | MERTKTYRO3AXLMAP4K1CHEK1 | |
| SCHEMBL25206869 | 0.89 | BTK (0.47) | MERTKTYRO3AXLMAP4K1EGFR | |
| SCHEMBL30412572 | 0.89 | BTK (0.47) | MERTKTYRO3AXLMAP4K1EGFR | |
| SCHEMBL25199628 | 0.89 | MERTK (0.46) | MERTKTYRO3AXLMAP4K1EGFR | |
| SCHEMBL25202712 | 0.89 | MERTK (0.46) | MERTKTYRO3AXLMAP4K1EGFR | |
| SCHEMBL30412120 | 0.89 | MERTK (0.46) | MERTKTYRO3AXLMAP4K1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4433059-A1 | THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF | Erasca, Inc. (US) | 2024-09-25 | — | — | EP | disclosed |
| WO-2023215494-A1 | THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF | ERASCA, INC. (US) | 2023-11-09 | — | — | WO | disclosed |
| WO-2023087027-A1 | THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF | ERASCA, INC. (US) | 2023-05-19 | — | — | WO | disclosed |