Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.55 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.55 |
| ▸ | MGAM | O43451 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SI | P14410 | 1/20 | 0.47 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 8/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | SCN4A | P35499 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.42 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL979602 | 1.00 | CSNK1A1 (0.55) | CSNK1A1CLK4MGAMGAASI | |
| SCHEMBL748850 | 0.81 | CSNK1A1 (0.50) | CSNK1A1CLK4ADORA2AADORA1CYP2D6 | |
| SCHEMBL3702933 | 0.79 | CYP2D6 (0.51) | CSNK1A1CLK4MGAMGAASI | |
| SCHEMBL17350861 | 0.77 | CSNK1A1 (0.45) | CSNK1A1CLK4MGAMGAASI | |
| SCHEMBL6374321 | 0.76 | CSNK1A1 (0.47) | CSNK1A1CLK4ADORA2AADORA1CYP2D6 | |
| SCHEMBL978392 | 0.75 | CYP2D6 (0.58) | CSNK1A1CLK4ADORA2AADORA1CYP2D6 | |
| SCHEMBL17350868 | 0.72 | ADORA2A (0.50) | CSNK1A1CLK4ADORA2AADORA1CYP2D6 | |
| SCHEMBL976510 | 0.71 | ADORA2A (0.71) | CSNK1A1CLK4ADORA2AADORA1KDM4E | |
| SCHEMBL976667 | 0.71 | CSNK1A1 (1.00) | CSNK1A1CLK4GAAADORA2AADORA1 | |
| SCHEMBL976598 | 0.70 | SCN9A (0.67) | CSNK1A1CLK4ADORA2AADORA1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3002280-B1 | CYCLIC TRIAZO AND DIAZO SODIUM CHANNEL BLOCKERS | UNIV GREENWICH (GB) | 2023-05-24 | — | — | EP | disclosed |