Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.72 |
| ▸ | FLT1 | P17948 | 1/20 | 0.72 |
| ▸ | FLT4 | P35916 | 1/20 | 0.72 |
| ▸ | BRAF | P15056 | 7/20 | 0.52 |
| ▸ | RAF1 | P04049 | 2/20 | 0.52 |
| ▸ | MET | P08581 | 5/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | KIF5B | P33176 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 3/20 | 0.48 |
| ▸ | TEK | Q02763 | 3/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fruquintinib SCHEMBL29366206 | 0.83 | KDR (1.00) | KDRFLT1FLT4BRAFRAF1 | |
| Fruquintinib SCHEMBL29516397 | 0.83 | KDR (1.00) | KDRFLT1FLT4BRAFRAF1 | |
| Fruquintinib SCHEMBL947183 | 0.83 | KDR (1.00) | KDRFLT1FLT4BRAFRAF1 | |
| SCHEMBL12909830 | 0.78 | KDR (0.87) | KDRFLT1FLT4BRAFRAF1 | |
| SCHEMBL945594 | 0.75 | KDR (0.83) | KDRFLT1FLT4BRAFRAF1 | |
| SCHEMBL11931698 | 0.74 | KDR (0.83) | KDRFLT1FLT4BRAFRAF1 | |
| SCHEMBL30753470 | 0.74 | KDR (0.79) | KDRFLT1FLT4 | |
| SCHEMBL30753458 | 0.74 | KDR (0.79) | KDRFLT1FLT4 | |
| SCHEMBL30753475 | 0.74 | KDR (0.79) | KDRFLT1FLT4 | |
| SCHEMBL945652 | 0.74 | KDR (0.68) | KDRFLT1FLT4RETKIF5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111018846-B | Crystalline forms of a compound | 和记黄埔医药（上海）有限公司 | 2023-06-06 | — | — | CN | claimed |
| CN-111018846-B | Crystalline forms of a compound | 和记黄埔医药（上海）有限公司 | 2023-06-06 | — | — | CN | disclosed |
| CN-111018846-B | Crystalline forms of a compound | 和记黄埔医药（上海）有限公司 | 2023-06-06 | — | — | CN | disclosed |