Known targets — ChEMBL curated mechanism
GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3B
The experimentally established mechanism targets of Lanicemine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D known ✓ | O15399 | 1/20 | 1.00 |
| ▸ | GRIN3B known ✓ | O60391 | 1/20 | 1.00 |
| ▸ | GRIN1 known ✓ | Q05586 | 1/20 | 1.00 |
| ▸ | GRIN2A known ✓ | Q12879 | 1/20 | 1.00 |
| ▸ | GRIN2B known ✓ | Q13224 | 1/20 | 1.00 |
| ▸ | GRIN2C known ✓ | Q14957 | 1/20 | 1.00 |
| ▸ | GRIN3A known ✓ | Q8TCU5 | 1/20 | 1.00 |
| ▸ | PTPRA | P18433 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.49 |
| ▸ | FDPS | P14324 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | SCN4A | P35499 | 2/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lanicemine SCHEMBL29379976 | 1.00 | GRIN2D (1.00) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Lanicemine SCHEMBL1422817 | 1.00 | GRIN2D (1.00) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Lanicemine SCHEMBL13557819 | 1.00 | GRIN2D (1.00) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Lanicemine SCHEMBL1650286 | 1.00 | GRIN2D (1.00) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Lanicemine SCHEMBL18094971 | 0.98 | GRIN2D (0.96) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Lanicemine SCHEMBL31444739 | 0.98 | GRIN2D (0.96) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Lanicemine SCHEMBL6021911 | 0.98 | GRIN2D (0.96) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Lanicemine SCHEMBL6021910 | 0.98 | GRIN2D (0.96) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Lanicemine SCHEMBL13517622 | 0.98 | GRIN2D (0.96) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Lanicemine SCHEMBL8779477 | 0.87 | GRIN2D (0.77) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111187202-B | NMDA antagonist prodrugs | 阿斯利康(瑞典)有限公司 | 2025-01-21 | — | — | CN | disclosed |
| EP-4168116-A1 | TOPICAL FORMULATIONS OF (1S)-1-PHENYL-2-PYRIDIN-2-YLETHANAMINE | Biohaven Therapeutics Ltd. (US) | 2023-04-26 | — | — | EP | disclosed |