Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 13/20 | 0.88 |
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.88 |
| ▸ | PIM1 | P11309 | 1/20 | 0.65 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.62 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.62 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.62 |
| ▸ | JAK2 | O60674 | 1/20 | 0.62 |
| ▸ | ABL1 | P00519 | 1/20 | 0.62 |
| ▸ | INSR | P06213 | 1/20 | 0.62 |
| ▸ | LCK | P06239 | 1/20 | 0.62 |
| ▸ | CSF1R | P07333 | 1/20 | 0.62 |
| ▸ | LYN | P07948 | 1/20 | 0.62 |
| ▸ | RET | P07949 | 1/20 | 0.62 |
| ▸ | IGF1R | P08069 | 1/20 | 0.62 |
| ▸ | MET | P08581 | 1/20 | 0.62 |
| ▸ | ROS1 | P08922 | 1/20 | 0.62 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.62 |
| ▸ | FGR | P09769 | 1/20 | 0.62 |
| ▸ | KIT | P10721 | 1/20 | 0.62 |
| ▸ | SRC | P12931 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13234450 | 0.94 | FYN (1.00) | FYNMKNK1PIM1NTRK1NTRK3 | |
| SCHEMBL3039017 | 0.94 | MKNK1 (1.00) | FYNMKNK1PIM1NTRK1NTRK3 | |
| SCHEMBL2945914 | 0.91 | FYN (0.78) | FYNMKNK1PIM1NTRK1NTRK3 | |
| SCHEMBL13223335 | 0.91 | MKNK1 (0.78) | FYNMKNK1PIM1NTRK1NTRK3 | |
| SCHEMBL2945039 | 0.91 | FYN (0.78) | FYNMKNK1PIM1NTRK1NTRK3 | |
| SCHEMBL2946475 | 0.91 | FYN (0.79) | FYNMKNK1PIM1NTRK1NTRK3 | |
| SCHEMBL13223340 | 0.89 | MKNK1 (0.74) | FYNMKNK1PIM1NTRK1NTRK3 | |
| SCHEMBL3036459 | 0.89 | MKNK1 (0.82) | FYNMKNK1PIM1NTRK1NTRK3 | |
| SCHEMBL13223409 | 0.88 | MKNK1 (0.73) | FYNMKNK1PIM1NTRK1NTRK3 | |
| SCHEMBL13223399 | 0.88 | MKNK1 (0.73) | FYNMKNK1PIM1NTRK1NTRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100216798-A1 | FUSED HETEROCYCLES AS LCK INHIBITORS | ASTELLAS PHARMA INC (JP) | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216798-A1 | FUSED HETEROCYCLES AS LCK INHIBITORS | LCK, ZAP70, FYN | FYN 3/4885MKNK1 816/4885PIM1 138/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.