Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30423084 | 0.90 | PTPN11 (0.50) | PTPN11MAPTMEN1TSHRKMT2A | |
| SCHEMBL16339057 | 0.87 | SUV39H2 (0.42) | PTPN11MAPTMEN1TSHRKMT2A | |
| SCHEMBL24032916 | 0.87 | PTPN11 (0.50) | PTPN11MAPTMEN1TSHRKMT2A | |
| SCHEMBL30423031 | 0.85 | PTPN11 (0.52) | PTPN11MAPTMEN1TSHRKMT2A | |
| SCHEMBL25439487 | 0.85 | BCL6 (0.41) | PTPN11MAPT | |
| Hydrochloric Acid SCHEMBL31148435 | 0.85 | BCL6 (0.40) | PTPN11MAPT | |
| Trifluoroacetic Acid SCHEMBL30423108 | 0.83 | PTPN11 (0.50) | PTPN11MAPTMEN1TSHRKMT2A | |
| SCHEMBL25421861 | 0.83 | PTPN11 (0.42) | PTPN11MAPTMEN1TSHRKMT2A | |
| SCHEMBL30422689 | 0.83 | PTPN11 (0.42) | PTPN11MAPTMEN1TSHRKMT2A | |
| SCHEMBL25096320 | 0.83 | PTPN11 (0.46) | PTPN11MAPTMEN1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4441042-A1 | 5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND METHODS OF USING THE SAME | Rgenta Therapeutics, Inc. (US) | 2024-10-09 | — | — | EP | disclosed |
| WO-2023102231-A1 | 5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND METHODS OF USING THE SAME | RGENTA THERAPEUTICS, INC. (US) | 2023-06-08 | — | — | WO | disclosed |