Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM6B | O15054 | 6/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 9/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 8/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | EP300 | Q09472 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24253862 | 1.00 | KDM6B (0.40) | KDM6BPDE10AHCRTR2HCRTR1CRHR1 | |
| SCHEMBL30424397 | 0.91 | KDM6B (0.39) | KDM6BHCRTR2HCRTR1KCNH2LTC4S | |
| SCHEMBL24253942 | 0.91 | KDM6B (0.39) | KDM6BHCRTR2HCRTR1KCNH2LTC4S | |
| SCHEMBL24253944 | 0.91 | KDM6B (0.39) | KDM6BHCRTR2HCRTR1KCNH2LTC4S | |
| SCHEMBL24253622 | 0.90 | KDM6B (0.39) | KDM6BHCRTR2HCRTR1KCNH2LTC4S | |
| SCHEMBL30423911 | 0.89 | KDM6B (0.39) | KDM6BHCRTR2HCRTR1KCNH2LTC4S | |
| SCHEMBL24253939 | 0.89 | KDM6B (0.39) | KDM6BHCRTR2HCRTR1KCNH2LTC4S | |
| SCHEMBL30423987 | 0.88 | HTT (0.40) | KDM6BHCRTR2HCRTR1 | |
| SCHEMBL24253831 | 0.88 | HTT (0.40) | KDM6BHCRTR2HCRTR1 | |
| SCHEMBL24253541 | 0.80 | F10 (0.32) | KDM6BHCRTR2HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4196478-A1 | HETEROARYL SUBSTITUTED SPIROPIPERIDINYL DERIVATIVES AND PHARMACEUTICAL USES THEREOF | Novartis AG (CH) | 2023-06-21 | — | — | EP | claimed |
| CN-116157404-A | Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof | 诺华股份有限公司 | 2023-05-23 | — | — | CN | claimed |
| EP-4196478-A1 | HETEROARYL SUBSTITUTED SPIROPIPERIDINYL DERIVATIVES AND PHARMACEUTICAL USES THEREOF | Novartis AG (CH) | 2023-06-21 | — | — | EP | disclosed |
| CN-116157404-A | Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof | 诺华股份有限公司 | 2023-05-23 | — | — | CN | disclosed |