Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 14/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25254154 | 1.00 | HDAC1 (0.39) | HDAC1HDAC6ROCK2PAK4PIM1 | |
| SCHEMBL25385686 | 0.92 | HDAC1 (0.38) | HDAC1HDAC6DPP4 | |
| SCHEMBL30425632 | 0.92 | HDAC1 (0.38) | HDAC1HDAC6DPP4 | |
| SCHEMBL30425209 | 0.91 | HDAC6 (0.37) | HDAC1HDAC6ROCK2PAK4PIM1 | |
| SCHEMBL25387287 | 0.91 | HDAC6 (0.37) | HDAC1HDAC6ROCK2PAK4PIM1 | |
| SCHEMBL25221486 | 0.91 | CDC7 (0.40) | HDAC6ROCK2PAK4PIM1GSK3B | |
| SCHEMBL30424969 | 0.91 | CDC7 (0.40) | HDAC6ROCK2PAK4PIM1GSK3B | |
| SCHEMBL25387070 | 0.89 | HDAC6 (0.37) | HDAC1HDAC6ROCK2PAK4PIM1 | |
| SCHEMBL30424911 | 0.89 | HDAC6 (0.37) | HDAC1HDAC6ROCK2PAK4PIM1 | |
| SCHEMBL25214570 | 0.88 | HDAC6 (0.49) | HDAC6ROCK2PIM1GSK3BAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116157398-B | Oxadiazole-based selective histone deacetylase 6 inhibitors | 意大发马克股份公司 | 2025-03-11 | — | — | CN | claimed |
| CN-116157398-A | 2- (4- ((5- (benzo [ b ] thiophen-3-yl) -1H-tetrazol-1-yl) methyl) phenyl) -5- (difluoromethyl) -1,3, 4-oxadiazole derivatives and similar compounds as selective inhibitors of histone deacetylase 6 (HDAC 6) for the treatment of, for example, peripheral neuropathy | 意大发马克股份公司 | 2023-05-23 | — | — | CN | claimed |
| CN-116157398-B | Oxadiazole-based selective histone deacetylase 6 inhibitors | 意大发马克股份公司 | 2025-03-11 | — | — | CN | disclosed |
| CN-116157398-A | 2- (4- ((5- (benzo [ b ] thiophen-3-yl) -1H-tetrazol-1-yl) methyl) phenyl) -5- (difluoromethyl) -1,3, 4-oxadiazole derivatives and similar compounds as selective inhibitors of histone deacetylase 6 (HDAC 6) for the treatment of, for example, peripheral neuropathy | 意大发马克股份公司 | 2023-05-23 | — | — | CN | disclosed |