Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.41 |
| ▸ | PRKCI | P41743 | 3/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.40 |
| ▸ | AXL | P30530 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | CDK9 | P50750 | 2/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15799693 | 1.00 | LRRK2 (0.41) | LRRK2PRKCIAURKBAXLAURKA | |
| SCHEMBL25245801 | 0.80 | PRKCI (0.42) | PRKCIAXLDAOPDPK1 | |
| SCHEMBL24348553 | 0.77 | PRKCI (0.32) | PRKCIDAOPDPK1 | |
| SCHEMBL2693931 | 0.77 | LRRK2 (0.41) | LRRK2PRKCIAURKBAXLAURKA | |
| SCHEMBL28813094 | 0.77 | GAA (0.50) | LRRK2PRKCIAURKBAXLAURKA | |
| SCHEMBL29514134 | 0.77 | LRRK2 (0.41) | LRRK2PRKCIAURKBAXLAURKA | |
| SCHEMBL30406172 | 0.77 | LRRK2 (0.41) | LRRK2PRKCIAURKBAXLAURKA | |
| SCHEMBL1944275 | 0.77 | LRRK2 (0.41) | LRRK2PRKCIAURKBAXLAURKA | |
| SCHEMBL2693973 | 0.73 | LRRK2 (0.38) | LRRK2PRKCIAURKBAXLAURKA | |
| SCHEMBL2691540 | 0.73 | AURKB (0.41) | LRRK2PRKCIAURKBAXLAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4436957-A1 | THERAPEUTIC INDAZOLE COMPOUNDS AND METHODS OF USE IN THE TREATMENT OF CANCER | Genentech, Inc. (US) | 2024-10-02 | — | — | EP | disclosed |
| CN-118302411-A | Therapeutic indazole compounds and methods of use thereof for the treatment of cancer | 基因泰克公司 | 2024-07-05 | — | — | CN | disclosed |
| WO-2023097195-A1 | THERAPEUTIC INDAZOLE COMPOUNDS AND METHODS OF USE IN THE TREATMENT OF CANCER | GENENTECH, INC. (US) | 2023-06-01 | — | — | WO | disclosed |