Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.53 |
| ▸ | GSK3B | P49841 | 9/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 9/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.44 |
| ▸ | PIM1 | P11309 | 6/20 | 0.44 |
| ▸ | KDR | P35968 | 5/20 | 0.44 |
| ▸ | CDC7 | O00311 | 4/20 | 0.43 |
| ▸ | ESRRG | P62508 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 4/20 | 0.40 |
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
| ▸ | PRKACA | P17612 | 3/20 | 0.40 |
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | CHUK | O15111 | 2/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.40 |
| ▸ | PRKCG | P05129 | 2/20 | 0.40 |
| ▸ | CDK1 | P06493 | 2/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25251038 | 1.00 | HDAC6 (0.53) | HDAC6GSK3BROCK2AURKBPIM1 | |
| SCHEMBL30424865 | 0.88 | HDAC6 (0.50) | HDAC6GSK3BROCK2AURKBPIM1 | |
| SCHEMBL25211647 | 0.88 | HDAC6 (0.50) | HDAC6GSK3BROCK2AURKBPIM1 | |
| SCHEMBL25241519 | 0.86 | HDAC6 (0.51) | HDAC6GSK3BROCK2AURKBPIM1 | |
| SCHEMBL25267504 | 0.86 | HDAC6 (0.51) | HDAC6GSK3BROCK2AURKBPIM1 | |
| SCHEMBL25214498 | 0.85 | HDAC6 (0.50) | HDAC6GSK3BROCK2AURKBPIM1 | |
| SCHEMBL25350232 | 0.83 | HDAC6 (0.57) | HDAC6GSK3BROCK2AURKBPIM1 | |
| SCHEMBL25352086 | 0.83 | HDAC6 (0.53) | HDAC6GSK3BROCK2AURKBPIM1 | |
| SCHEMBL25215233 | 0.82 | HDAC6 (0.52) | HDAC6GSK3BROCK2AURKBPIM1 | |
| SCHEMBL30424426 | 0.82 | HDAC6 (0.52) | HDAC6GSK3BROCK2AURKBPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116157398-B | Oxadiazole-based selective histone deacetylase 6 inhibitors | 意大发马克股份公司 | 2025-03-11 | — | — | CN | claimed |
| CN-116157398-A | 2- (4- ((5- (benzo [ b ] thiophen-3-yl) -1H-tetrazol-1-yl) methyl) phenyl) -5- (difluoromethyl) -1,3, 4-oxadiazole derivatives and similar compounds as selective inhibitors of histone deacetylase 6 (HDAC 6) for the treatment of, for example, peripheral neuropathy | 意大发马克股份公司 | 2023-05-23 | — | — | CN | claimed |
| CN-116157398-B | Oxadiazole-based selective histone deacetylase 6 inhibitors | 意大发马克股份公司 | 2025-03-11 | — | — | CN | disclosed |
| CN-116157398-A | 2- (4- ((5- (benzo [ b ] thiophen-3-yl) -1H-tetrazol-1-yl) methyl) phenyl) -5- (difluoromethyl) -1,3, 4-oxadiazole derivatives and similar compounds as selective inhibitors of histone deacetylase 6 (HDAC 6) for the treatment of, for example, peripheral neuropathy | 意大发马克股份公司 | 2023-05-23 | — | — | CN | disclosed |