Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 1/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | CCND3 | P30281 | 1/20 | 0.49 |
| ▸ | CDK9 | P50750 | 1/20 | 0.49 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 6/20 | 0.44 |
| ▸ | STK17B | O94768 | 1/20 | 0.41 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 3/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.38 |
| ▸ | MAP3K7 | O43318 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.38 |
| ▸ | INSR | P06213 | 2/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26655582 | 1.00 | CCNK (0.49) | CCNKCCNA2CDK2CCND3CDK9 | |
| SCHEMBL25004485 | 0.86 | NOTUM (0.55) | ALKEGFRNOTUMMAP3K7MAPK1 | |
| SCHEMBL25005396 | 0.83 | MAP3K7 (0.44) | CCNKCCNA2CDK2CCND3CDK9 | |
| SCHEMBL25005398 | 0.80 | NOTUM (0.47) | ALKEGFRNOTUMMAP3K7MAPK1 | |
| SCHEMBL29114931 | 0.79 | EGFR (0.43) | CCNKCCNA2CDK2CCND3CDK9 | |
| SCHEMBL25005397 | 0.78 | MAP3K7 (0.43) | ALKEGFRMAP3K7MAPK1MAP2K1 | |
| SCHEMBL30425857 | 0.76 | ALK (0.70) | CDK2ALKSTK17BSTK17AEGFR | |
| SCHEMBL26655424 | 0.76 | ALK (0.70) | CDK2ALKSTK17BSTK17AEGFR | |
| SCHEMBL31147629 | 0.76 | NOTUM (0.50) | ALKNOTUM | |
| SCHEMBL27237971 | 0.76 | NOTUM (0.50) | ALKNOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116249690-A | Indoline compounds and derivatives as EGFR inhibitors | 百济神州有限公司 | 2023-06-09 | — | — | CN | disclosed |