Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25389860 | 1.00 | HDAC6 (0.51) | HDAC6NPC1RAB9AHDAC1NFKB1 | |
| SCHEMBL25386636 | 0.91 | HDAC6 (0.54) | HDAC6NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30425876 | 0.91 | HDAC6 (0.54) | HDAC6NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30424894 | 0.90 | HDAC6 (0.60) | HDAC6NPC1RAB9A | |
| SCHEMBL25386805 | 0.90 | HDAC6 (0.60) | HDAC6NPC1RAB9A | |
| SCHEMBL25218182 | 0.90 | HDAC6 (0.47) | HDAC6NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL30424292 | 0.90 | HDAC6 (0.47) | HDAC6NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL25387529 | 0.88 | HDAC6 (0.47) | HDAC6NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL30424649 | 0.88 | HDAC6 (0.47) | HDAC6NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL25389287 | 0.88 | HDAC6 (0.49) | HDAC6NPC1RAB9AHDAC1NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116157398-B | Oxadiazole-based selective histone deacetylase 6 inhibitors | 意大发马克股份公司 | 2025-03-11 | — | — | CN | claimed |
| CN-116157398-A | 2- (4- ((5- (benzo [ b ] thiophen-3-yl) -1H-tetrazol-1-yl) methyl) phenyl) -5- (difluoromethyl) -1,3, 4-oxadiazole derivatives and similar compounds as selective inhibitors of histone deacetylase 6 (HDAC 6) for the treatment of, for example, peripheral neuropathy | 意大发马克股份公司 | 2023-05-23 | — | — | CN | claimed |
| CN-116157398-B | Oxadiazole-based selective histone deacetylase 6 inhibitors | 意大发马克股份公司 | 2025-03-11 | — | — | CN | disclosed |
| CN-116157398-A | 2- (4- ((5- (benzo [ b ] thiophen-3-yl) -1H-tetrazol-1-yl) methyl) phenyl) -5- (difluoromethyl) -1,3, 4-oxadiazole derivatives and similar compounds as selective inhibitors of histone deacetylase 6 (HDAC 6) for the treatment of, for example, peripheral neuropathy | 意大发马克股份公司 | 2023-05-23 | — | — | CN | disclosed |