Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 2/20 | 0.72 |
| ▸ | MC4R | P32245 | 3/20 | 0.68 |
| ▸ | MC5R | P33032 | 2/20 | 0.68 |
| ▸ | MC3R | P41968 | 2/20 | 0.68 |
| ▸ | MC1R | Q01726 | 2/20 | 0.68 |
| ▸ | CTSL | P07711 | 3/20 | 0.63 |
| ▸ | CTSS | P25774 | 3/20 | 0.63 |
| ▸ | CTSK | P43235 | 3/20 | 0.63 |
| ▸ | CTSH | P09668 | 1/20 | 0.63 |
| ▸ | CXCR4 | P61073 | 10/20 | 0.60 |
| ▸ | IL23R | Q5VWK5 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30800876 | 0.97 | C5AR1 (0.72) | C5AR1MC4RMC5RMC3RMC1R | |
| SCHEMBL29533782 | 0.93 | C5AR1 (0.77) | C5AR1MC4RMC5RMC3RMC1R | |
| SCHEMBL18281737 | 0.93 | MC4R (0.77) | C5AR1MC4RMC5RMC3RMC1R | |
| SCHEMBL18281742 | 0.93 | MC4R (0.77) | C5AR1MC4RMC5RMC3RMC1R | |
| SCHEMBL30312751 | 0.93 | MC4R (0.77) | C5AR1MC4RMC5RMC3RMC1R | |
| SCHEMBL29533733 | 0.92 | MC4R (0.78) | C5AR1MC4RMC5RMC3RMC1R | |
| SCHEMBL29533913 | 0.92 | C5AR1 (0.75) | C5AR1MC4RMC5RMC3RMC1R | |
| SCHEMBL30427910 | 0.92 | C5AR1 (0.62) | C5AR1MC4RMC5RMC3RMC1R | |
| SCHEMBL29430238 | 0.91 | MC4R (0.78) | C5AR1MC4RMC5RMC3RMC1R | |
| SCHEMBL3060138 | 0.91 | C5AR1 (0.73) | C5AR1MC4RMC5RMC3RMC1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091689-A1 | COMBINED USE OF MCR1-DIRECTED RADIOTHERAPY AND IMMUNE CHECKPOINT INHIBITION IN THE TREATMENT OF MELANOMA | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2023-05-25 | — | — | WO | disclosed |