Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 3/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30429426 | 0.86 | PRMT5 (0.43) | MAPK1UCHL1PRMT5WDR77GPR119 | |
| SCHEMBL8222337 | 0.85 | DRD4 (0.48) | MEN1KMT2AMAPK1NAMPTDDB1 | |
| SCHEMBL5184687 | 0.84 | NAMPT (0.46) | MEN1KMT2AMAPK1NAMPTDDB1 | |
| SCHEMBL205299 | 0.83 | ACE (0.54) | MEN1KMT2AMAPK1NAMPTDDB1 | |
| SCHEMBL31038337 | 0.83 | ACE (0.54) | MEN1KMT2AMAPK1NAMPTDDB1 | |
| SCHEMBL24038973 | 0.83 | MEN1 (0.45) | MEN1KMT2AMAPK1NAMPTDDB1 | |
| SCHEMBL30626775 | 0.83 | ACE (0.54) | MEN1KMT2AMAPK1NAMPTDDB1 | |
| SCHEMBL30944609 | 0.83 | MEN1 (0.45) | MEN1KMT2AMAPK1NAMPTDDB1 | |
| SCHEMBL5208845 | 0.83 | ACE (0.54) | MEN1KMT2AMAPK1NAMPTDDB1 | |
| SCHEMBL27393607 | 0.83 | MEN1 (0.45) | MEN1KMT2AMAPK1NAMPTDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111511750-B | Macrocyclic derivatives, process for their preparation and pharmaceutical compositions containing them | 法国施维雅药厂 | 2023-06-13 | — | — | CN | disclosed |