SCHEMBL30429232

SCHEMBL30429232

Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCCC(=O)O)CC2)n1

nearest known ligand 0.87

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 5/20 0.87
HDAC4 P56524 5/20 0.87
HDAC1 Q13547 5/20 0.87
HDAC7 Q8WUI4 5/20 0.87
HDAC2 Q92769 5/20 0.87
HDAC10 Q969S8 5/20 0.87
HDAC11 Q96DB2 5/20 0.87
HDAC8 Q9BY41 5/20 0.87
HDAC6 Q9UBN7 5/20 0.87
HDAC9 Q9UKV0 5/20 0.87
HDAC5 Q9UQL6 5/20 0.87
ABL1 P00519 9/20 0.84
SRC P12931 8/20 0.84
LCK P06239 5/20 0.84
PKMYT1 Q99640 3/20 0.84
EPHB6 O15197 2/20 0.84
EGFR P00533 2/20 0.84
FYN P06241 2/20 0.84
CSF1R P07333 2/20 0.84
YES1 P07947 2/20 0.84

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25243991 1.00 HDAC3 (0.87) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL25208971 0.98 HDAC3 (0.87) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL30429404 0.98 HDAC3 (0.87) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL24950237 0.97 HDAC3 (0.87) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL29816962 0.97 HDAC3 (0.87) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL23120552 0.97 HDAC3 (0.87) HDAC3HDAC4HDAC1HDAC7HDAC2
Dasatinib Anhydrous SCHEMBL16416414 0.95 ABL1 (0.90) HDAC3HDAC4HDAC1HDAC7HDAC2
Dasatinib Anhydrous SCHEMBL28406464 0.94 ABL1 (0.93) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL28935340 0.93 ABL1 (0.87) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL29618215 0.93 ABL1 (0.87) HDAC3HDAC4HDAC1HDAC7HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023096995-A1 COMPOSITIONS AND METHODS COMPRISING SUBSTITUTED N-(2-CHLORO-6-METHYLPHENYL)-2-((6-(6-MEMBERED HETEROCYCLOALKYL)-2-METHYLPYRIMIDIN-4-YL)AMINO)THIAZOLE-5-CARBOXAMIDE ANALOGUES ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. (US) 2023-06-01 WO disclosed