Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.54 |
| ▸ | NPC1 | O15118 | 6/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | RAF1 | P04049 | 3/20 | 0.49 |
| ▸ | BRAF | P15056 | 3/20 | 0.49 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.47 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29505352 | 0.81 | HRH3 (0.46) | RAB9ANPC1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL16896463 | 0.81 | HRH3 (0.46) | RAB9ANPC1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL16896364 | 0.79 | PLAU (0.45) | RAF1BRAFLRRK2 | |
| SCHEMBL29505200 | 0.79 | PLAU (0.45) | RAF1BRAFLRRK2 | |
| SCHEMBL29662196 | 0.78 | IRAK4 (0.61) | RAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL16896618 | 0.78 | IRAK4 (0.61) | RAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL16896607 | 0.77 | HRH3 (0.47) | RAB9ANPC1SMN1; SMN2HTTMEN1 | |
| SCHEMBL29505292 | 0.77 | HRH3 (0.47) | RAB9ANPC1SMN1; SMN2HTTMEN1 | |
| SCHEMBL16896444 | 0.77 | HRH3 (0.45) | RAF1BRAFLRRK2 | |
| SCHEMBL18243749 | 0.77 | IRAK4 (0.48) | RAB9ANPC1ALDH1A1MEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3600270-B1 | COMPOUNDS AND COMPOSITIONS FOR TREATING HEMATOLOGICAL DISORDERS | AURIGENE ONCOLOGY LTD (IN) | 2023-06-14 | — | — | EP | claimed |