Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 19/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25253561 | 1.00 | KRAS (0.43) | KRASCNR2 | |
| SCHEMBL25253562 | 1.00 | KRAS (0.43) | KRASCNR2 | |
| SCHEMBL29281585 | 0.91 | KRAS (0.37) | KRASCNR2 | |
| SCHEMBL29281581 | 0.91 | KRAS (0.37) | KRASCNR2 | |
| SCHEMBL25334910 | 0.89 | KRAS (0.41) | KRASCNR2 | |
| SCHEMBL25371293 | 0.89 | KRAS (0.45) | KRAS | |
| SCHEMBL25338764 | 0.87 | KRAS (0.47) | KRAS | |
| SCHEMBL25209790 | 0.87 | KRAS (0.47) | KRAS | |
| SCHEMBL25438046 | 0.86 | KRAS (0.46) | KRAS | |
| SCHEMBL24535869 | 0.85 | KRAS (0.42) | KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4436571-A1 | SMALL MOLECULE INHIBITORS OF KRAS MUTATED PROTEINS | Merck Sharp & Dohme LLC (US) | 2024-10-02 | — | — | EP | disclosed |
| WO-2023097227-A1 | SMALL MOLECULE INHIBITORS OF KRAS MUTATED PROTEINS | MERCK SHARP & DOHME LLC (US) | 2023-06-01 | — | — | WO | disclosed |