Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 16/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.72 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.57 |
| ▸ | IKBKB | O14920 | 1/20 | 0.55 |
| ▸ | FYN | P06241 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3043399 | 1.00 | PIM1 (0.72) | PIM1KCNH2MKNK1IKBKBFYN | |
| SCHEMBL3033472 | 0.91 | PIM1 (0.66) | PIM1KCNH2MKNK1IKBKBFYN | |
| SCHEMBL3033474 | 0.91 | PIM1 (0.66) | PIM1KCNH2MKNK1IKBKBFYN | |
| SCHEMBL3037427 | 0.90 | PIM1 (0.71) | PIM1KCNH2MKNK1FYN | |
| SCHEMBL3037431 | 0.90 | PIM1 (0.71) | PIM1KCNH2MKNK1FYN | |
| SCHEMBL3040947 | 0.90 | PIM1 (0.74) | PIM1KCNH2FYN | |
| SCHEMBL2940384 | 0.90 | PIM1 (0.74) | PIM1KCNH2FYN | |
| SCHEMBL1051060 | 0.88 | PIM1 (0.72) | PIM1KCNH2MKNK1FYN | |
| SCHEMBL3040085 | 0.88 | PIM1 (0.67) | PIM1KCNH2MKNK1FYN | |
| SCHEMBL3040087 | 0.88 | PIM1 (0.67) | PIM1KCNH2MKNK1FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100216798-A1 | FUSED HETEROCYCLES AS LCK INHIBITORS | ASTELLAS PHARMA INC (JP) | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216798-A1 | FUSED HETEROCYCLES AS LCK INHIBITORS | LCK, ZAP70, FYN | PIM1 138/4885KCNH2 235/4885MKNK1 816/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.