SCHEMBL30436711

SCHEMBL30436711

N#Cc1ccc(F)c(C(=O)Nc2ccnc(-c3ccc(F)cc3)c2)c1

nearest known ligand 0.80

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
PPARG P37231 4/20 0.80
GRM5 P41594 6/20 0.52
CSNK1D P48730 1/20 0.47
CSNK1E P49674 1/20 0.47
LCLAT1 Q6UWP7 2/20 0.44
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
GAA P10253 1/20 0.43
MAPT P10636 1/20 0.43
SCN8A Q9UQD0 1/20 0.42
SCN10A Q9Y5Y9 1/20 0.42
PKM P14618 1/20 0.41
GRM4 Q14833 2/20 0.41
TMPRSS4 Q9NRS4 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21055990 1.00 PPARG (0.80) PPARGGRM5CSNK1DCSNK1ELCLAT1
SCHEMBL30436815 0.91 PPARG (0.67) PPARGGRM5LCLAT1MEN1KMT2A
SCHEMBL21056004 0.91 PPARG (0.67) PPARGGRM5LCLAT1MEN1KMT2A
SCHEMBL21056010 0.89 PPARG (1.00) PPARGGRM5SCN8ASCN10AGRM4
SCHEMBL30437472 0.89 PPARG (1.00) PPARGGRM5SCN8ASCN10AGRM4
SCHEMBL30436387 0.86 PPARG (0.78) PPARGGRM5LCLAT1MAPT
SCHEMBL21056003 0.86 PPARG (0.78) PPARGGRM5LCLAT1MAPT
SCHEMBL21056011 0.85 PPARG (0.64) PPARGGRM5CSNK1DCSNK1EMEN1
SCHEMBL30435682 0.85 PPARG (0.64) PPARGGRM5CSNK1DCSNK1EMEN1
SCHEMBL21118938 0.83 PPARG (0.56) PPARGGRM5LCLAT1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111630030-B Novel benzamide derivatives as PPAR-gamma modulators 梅迪比奥法尔玛公司 2023-06-20 CN claimed
CN-111630030-B Novel benzamide derivatives as PPAR-gamma modulators 梅迪比奥法尔玛公司 2023-06-20 CN disclosed