Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 3/20 | 0.64 |
| ▸ | MAPK8 | P45983 | 13/20 | 0.60 |
| ▸ | MAPK9 | P45984 | 12/20 | 0.60 |
| ▸ | MAPK10 | P53779 | 10/20 | 0.60 |
| ▸ | GSK3B | P49841 | 4/20 | 0.55 |
| ▸ | CDK2 | P24941 | 3/20 | 0.55 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.55 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.55 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.55 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.55 |
| ▸ | IKBKB | O14920 | 1/20 | 0.55 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.55 |
| ▸ | MAP2K6 | P52564 | 1/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.52 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.52 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.52 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25198290 | 0.87 | MAPK8 (0.54) | RETMAPK8MAPK9MAPK10GSK3B | |
| SCHEMBL30356758 | 0.87 | MAPK8 (0.54) | RETMAPK8MAPK9MAPK10GSK3B | |
| SCHEMBL26813998 | 0.81 | KDM4E (0.64) | RETMAPK8MAPK9MAPK10GSK3B | |
| SCHEMBL17730228 | 0.81 | KDM4E (0.64) | RETMAPK8MAPK9MAPK10GSK3B | |
| SCHEMBL17730226 | 0.81 | KDM4E (0.64) | RETMAPK8MAPK9MAPK10GSK3B | |
| SCHEMBL3769935 | 0.79 | RET (1.00) | RETMAPK8MAPK9MAPK10GSK3B | |
| SCHEMBL3769946 | 0.79 | RET (1.00) | RETMAPK8MAPK9MAPK10GSK3B | |
| SCHEMBL3776172 | 0.76 | CCNB2 (0.80) | RETMAPK8MAPK9MAPK10GSK3B | |
| SCHEMBL3776164 | 0.76 | CCNB2 (0.80) | RETMAPK8MAPK9MAPK10GSK3B | |
| SCHEMBL8233929 | 0.76 | RET (0.56) | RETMAPK8MAPK9MAPK10GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116209658-A | Inhibitors of RHO-associated coiled coil kinase | 安吉昂生物医药公司 | 2023-06-02 | — | — | CN | disclosed |