Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 7/20 | 0.37 |
| ▸ | ELOVL6 | Q9H5J4 | 6/20 | 0.37 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.36 |
| ▸ | GSK3B | P49841 | 3/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.35 |
| ▸ | ELOVL3 | Q9HB03 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL30439111 | 0.96 | AKR1C3 (0.37) | AKR1C3ELOVL6CYP17A1DYRK1AGSK3B | |
| SCHEMBL30438994 | 0.94 | DYRK1A (0.39) | AKR1C3ELOVL6DYRK1AGSK3BCHEK1 | |
| SCHEMBL25257863 | 0.94 | DYRK1A (0.39) | AKR1C3ELOVL6DYRK1AGSK3BCHEK1 | |
| Hydrochloric Acid SCHEMBL30439503 | 0.93 | DYRK1A (0.38) | AKR1C3ELOVL6CYP17A1DYRK1AGSK3B | |
| SCHEMBL25213710 | 0.90 | DYRK1A (0.38) | AKR1C3DYRK1AGSK3BCHEK1 | |
| SCHEMBL30438490 | 0.90 | DYRK1A (0.38) | AKR1C3DYRK1AGSK3BCHEK1 | |
| Hydrochloric Acid SCHEMBL30438968 | 0.89 | DYRK1A (0.37) | AKR1C3DYRK1AGSK3BCHEK1 | |
| Sulfuric Acid SCHEMBL30439116 | 0.86 | AKR1C3 (0.38) | AKR1C3CYP17A1DYRK1AGSK3BCHEK1 | |
| Trifluoroacetic Acid SCHEMBL30439151 | 0.82 | EGLN2 (0.41) | AKR1C3CYP17A1KDM1AHDAC1CHEK1 | |
| SCHEMBL25250558 | 0.81 | AKR1C3 (0.38) | AKR1C3CYP17A1DYRK1AGSK3BKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250122167-A1 | Pyrazine Compounds Useful in the Treatment of Parasitic Protozoal Infection | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2025-04-17 | — | — | US | disclosed |
| EP-4436960-A1 | PYRAZINE COMPOUNDS USEFUL IN THE TREATMENT OF PARASITIC PROTOZOAL INFECTION | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2024-10-02 | — | — | EP | disclosed |
| WO-2023094305-A1 | PYRAZINE COMPOUNDS USEFUL IN THE TREATMENT OF PARASITIC PROTOZOAL INFECTION | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2023-06-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250122167-A1 | Pyrazine Compounds Useful in the Treatment of Parasitic Protozoal Infection | CYP3A5, CYP3A43, CYP51A1 | AKR1C3 1239/4885ELOVL6 4789/4885CYP17A1 690/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.