Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 4/20 | 0.80 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.80 |
| ▸ | GAK | O14976 | 1/20 | 0.80 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.80 |
| ▸ | ULK1 | O75385 | 1/20 | 0.80 |
| ▸ | STK10 | O94804 | 1/20 | 0.80 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.80 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.80 |
| ▸ | LATS1 | O95835 | 1/20 | 0.80 |
| ▸ | PAK4 | O96013 | 1/20 | 0.80 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.80 |
| ▸ | LCK | P06239 | 1/20 | 0.80 |
| ▸ | CDK1 | P06493 | 1/20 | 0.80 |
| ▸ | APRT | P07741 | 1/20 | 0.80 |
| ▸ | RET | P07949 | 1/20 | 0.80 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.80 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.80 |
| ▸ | NQO2 | P16083 | 1/20 | 0.80 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.80 |
| ▸ | FECH | P22830 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27030775 | 1.00 | FLT3 (0.80) | FLT3IRAK4GAKRIPK2ULK1 | |
| SCHEMBL27030604 | 0.90 | FLT3 (0.85) | FLT3IRAK4GAKRIPK2ULK1 | |
| SCHEMBL30775111 | 0.90 | FLT3 (0.85) | FLT3IRAK4GAKRIPK2ULK1 | |
| Crenolanib SCHEMBL30002138 | 0.89 | FLT3 (1.00) | FLT3IRAK4GAKRIPK2ULK1 | |
| Crenolanib SCHEMBL29350134 | 0.89 | FLT3 (1.00) | FLT3IRAK4GAKRIPK2ULK1 | |
| Crenolanib SCHEMBL2730601 | 0.89 | FLT3 (1.00) | FLT3IRAK4GAKRIPK2ULK1 | |
| Crenolanib SCHEMBL29352568 | 0.89 | FLT3 (1.00) | FLT3IRAK4GAKRIPK2ULK1 | |
| SCHEMBL25290500 | 0.88 | IRAK4 (0.66) | FLT3IRAK4GAKRIPK2ULK1 | |
| SCHEMBL29450889 | 0.88 | IRAK4 (0.66) | FLT3IRAK4GAKRIPK2ULK1 | |
| SCHEMBL22567082 | 0.85 | IRAK4 (0.86) | FLT3IRAK4GAKRIPK2ULK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024233967-A2 | SIK INHIBITORS TO TREAT CHRONIC KIDNEY DISEASE | THE GENERAL HOSPITAL CORPORATION (US) | 2024-11-14 | — | — | WO | disclosed |
| CN-116234549-A | Salt-induced kinase inhibitors | 总医院公司 | 2023-06-06 | — | — | CN | disclosed |