Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 14/20 | 0.50 |
| ▸ | DDB1 | Q16531 | 13/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25502422 | 1.00 | CRBN (0.50) | CRBNDDB1ALDH1A1NPC1MAPT | |
| SCHEMBL25502446 | 0.88 | DDB1 (0.48) | CRBNDDB1ALDH1A1NPC1MAPT | |
| SCHEMBL30442388 | 0.87 | CRBN (0.56) | CRBNDDB1POLB | |
| SCHEMBL25199468 | 0.86 | CRBN (0.44) | CRBNDDB1GSPT1POLBPTPN1 | |
| SCHEMBL30441406 | 0.86 | CRBN (0.44) | CRBNDDB1GSPT1POLBPTPN1 | |
| SCHEMBL25184855 | 0.86 | CRBN (0.44) | CRBNDDB1GSPT1POLBPTPN1 | |
| SCHEMBL25205685 | 0.85 | CRBN (0.51) | CRBNDDB1POLB | |
| SCHEMBL25189125 | 0.85 | DDB1 (0.47) | CRBNDDB1 | |
| SCHEMBL25264962 | 0.85 | DDB1 (0.47) | CRBNDDB1 | |
| SCHEMBL25190965 | 0.85 | CRBN (0.48) | CRBNDDB1MAPTL3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4430052-A1 | BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF | Nurix Therapeutics, Inc. (US) | 2024-09-18 | — | — | EP | disclosed |
| WO-2023086399-A1 | BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF | NURIX THERAPEUTICS, INC. (US) | 2023-05-19 | — | — | WO | disclosed |