Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 11/20 | 0.72 |
| ▸ | CRBN | Q96SW2 | 11/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.44 |
| ▸ | WNT3A | P56704 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25221368 | 1.00 | DDB1 (0.72) | DDB1CRBNALDH1A1NPC1MAPT | |
| SCHEMBL30442388 | 0.88 | CRBN (0.56) | DDB1CRBNJAK1SYKPRMT5 | |
| SCHEMBL30769278 | 0.87 | DDB1 (0.67) | DDB1CRBNALDH1A1NPC1MAPT | |
| SCHEMBL25143681 | 0.85 | DDB1 (0.67) | DDB1CRBNMAPTPRMT5GPR119 | |
| SCHEMBL25074522 | 0.85 | CRBN (0.70) | DDB1CRBNGPR119 | |
| SCHEMBL30201627 | 0.85 | CRBN (0.70) | DDB1CRBNGPR119 | |
| SCHEMBL24881041 | 0.85 | CRBN (0.70) | DDB1CRBNGPR119 | |
| SCHEMBL30201796 | 0.85 | DDB1 (0.67) | DDB1CRBNMAPTPRMT5GPR119 | |
| SCHEMBL29208509 | 0.85 | CRBN (0.70) | DDB1CRBNGPR119 | |
| SCHEMBL29977355 | 0.85 | CRBN (0.70) | DDB1CRBNGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4430052-A1 | BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF | Nurix Therapeutics, Inc. (US) | 2024-09-18 | — | — | EP | disclosed |
| WO-2023086399-A1 | BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF | NURIX THERAPEUTICS, INC. (US) | 2023-05-19 | — | — | WO | disclosed |