⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1150608 | 0.59 | — | — | |
| SCHEMBL3427593 | 0.53 | — | — | |
| Iodide SCHEMBL8151277 | 0.51 | — | — | |
| SCHEMBL1819677 | 0.50 | — | — | |
| SCHEMBL15062331 | 0.45 | CYP2D6 (0.30) | — | |
| SCHEMBL16274880 | 0.45 | — | — | |
| SCHEMBL85409 | 0.45 | — | — | |
| SCHEMBL11937064 | 0.45 | — | — | |
| SCHEMBL18175523 | 0.42 | — | — | |
| SCHEMBL4156321 | 0.38 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 165 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2350068-B1 | UREA DERIVATIVES OF SUBSTITUTED NORTROPANES, MEDICAMENTS CONTAINING SUCH COMPOUNDS AND THEIR USE | BOEHRINGER INGELHEIM INT (DE) | 2017-08-30 | — | — | EP | claimed |
| US-20160067241-A1 | COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF SUBOPTIMALLY ADMINISTERED CHEMICAL COMPOUNDS INCLUDING SUBSTITUTED NAPHTHALIMIDES SUCH AS AMONAFIDE FOR THE TREATMENT OF IMMUNOLOGICAL, METABOLIC, INFECTIOUS, AND BENIGN OR NEOPLASTIC HYPERPROLIFERATIVE DISEASE CONDITIONS | BROWN DENNIS M (US) | 2016-03-10 | — | — | US | claimed |
| EP-2300417-B1 | PROCESS FOR PREPARING 2-(AMINOMETHYLIDENE)-4,4-DIFLUORO-3-OXOBUTYRIC ESTERS | BASF SE (DE) | 2015-07-22 | — | — | EP | claimed |
| WO-2014179528-A2 | COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF SUBOPTIMALLY ADMINISTERED CHEMICAL COMPOUNDS INCLUDING SUBSTITUTED NAPHTHALIMIDES SUCH AS AMONAFIDE FOR THE TREATMENT OF IMMUNOLOGICAL, METABOLIC, INFECTIOUS, AND BENIGN OR NEOPLASTIC HYPERPROLIFERATIVE DISEASE CONDITIONS | BROWN DENNIS M (US) | 2014-11-06 | — | — | WO | claimed |
| US-8829027-B2 | Urea derivatives of substituted nortropanes, medicaments containing such compounds and their use | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-09-09 | — | — | US | claimed |
| US-8586750-B2 | Method for the production of halogen-substituted 2-(aminomethylidene)-3-oxobutyric acid esters | BASF SE (DE) | 2013-11-19 | — | — | US | claimed |
| US-8314233-B2 | Process for preparing 2-(aminomethylidene)-4,4-difluoro-3-oxobutyric esters | BASF SE (DE) | 2012-11-20 | — | — | US | claimed |
| EP-2297111-B1 | METHOD FOR THE PRODUCTION OF HALOGEN-SUBSTITUTED 2-(AMINOMETHYLIDENE)-3- OXOBUTYRIC ACID ESTERS | BASF SE (DE) | 2012-06-20 | — | — | EP | claimed |
| US-20110275595-A1 | Urea derivatives of substituted nortropanes, medicaments containing such compounds and their use | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-11-10 | — | — | US | claimed |
| EP-2245014-B1 | UREA DERIVATIVES OF BENZOMORPHANES AND RELATED SCAFFOLDS, MEDICAMENTS CONTAINING SUCH COMPOUNDS AND THEIR USE | BOEHRINGER INGELHEIM INT (DE) | 2011-11-02 | — | — | EP | claimed |
| US-20080063714-A1 | Compositions for Encapsulation and Controlled Release | 3M INNOVATIVE PROPERTIES COMPANY | 2008-03-13 | — | — | US | claimed |
| US-20080039533-A1 | Bioactive Compositions Comprising Triazines | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2008-02-14 | — | — | US | claimed |
| US-7247723-B2 | Metallic chromonic compounds | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2007-07-24 | — | — | US | claimed |
| US-20060110528-A1 | Method for making metallic nanostructures | 3M INNOVATIVE PROPERTIES COMPANY | 2006-05-25 | — | — | US | claimed |
| US-20060110922-A1 | Metallic chromonic compounds | 3M INNOVATIVE PROPERTIES COMPANY | 2006-05-25 | — | — | US | claimed |
| EP-1651035-A2 | COMPOSITIONS FOR ENCAPSULATION AND CONTROLLED RELEASE | 3M Innovative Properties Company (US) | 2006-05-03 | — | — | EP | claimed |
| EP-1651185-A1 | BIOACTIVE COMPOSITIONS COMPRISING TRIAZINES | 3M Innovative Properties Company (US) | 2006-05-03 | — | — | EP | claimed |
| WO-2005012488-A2 | COMPOSITIONS FOR ENCAPSULATION AND CONTROLLED RELEASE | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2005-02-10 | — | — | WO | claimed |
| WO-2005011629-A1 | BIOACTIVE COMPOSITIONS COMPRISING TRIAZINES | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2005-02-10 | — | — | WO | claimed |
| US-4428935-A | BETA-LACTAMASE INHIBITORS | PFIZER INC. (US) | 1984-01-31 | — | — | US | claimed |