Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 19/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20168342 | 1.00 | KCNJ1 (0.40) | KCNJ1KCNH2P2RX7 | |
| SCHEMBL30445053 | 0.83 | KCNJ1 (0.45) | KCNJ1P2RX7 | |
| SCHEMBL20168352 | 0.83 | KCNJ1 (0.45) | KCNJ1P2RX7 | |
| SCHEMBL30444275 | 0.80 | KCNJ1 (0.40) | KCNJ1KCNH2P2RX7 | |
| SCHEMBL20574919 | 0.80 | KCNJ1 (0.40) | KCNJ1KCNH2P2RX7 | |
| SCHEMBL30445023 | 0.80 | KCNJ1 (0.44) | KCNJ1KCNH2 | |
| SCHEMBL20168545 | 0.80 | KCNJ1 (0.44) | KCNJ1KCNH2 | |
| SCHEMBL20574979 | 0.78 | KCNJ1 (0.42) | KCNJ1KCNH2 | |
| SCHEMBL20575137 | 0.78 | KCNJ1 (0.42) | KCNJ1KCNH2 | |
| SCHEMBL30444323 | 0.78 | KCNJ1 (0.42) | KCNJ1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110139862-B | Substituted bicyclic heterocyclic derivatives useful as ROMK channel inhibitors | 百时美施贵宝公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-110678463-B | Substituted nitrogen-containing compounds | 百时美施贵宝公司 | 2023-06-06 | — | — | CN | disclosed |