Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 4/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 11/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20176989 | 1.00 | KCNJ1 (0.51) | KCNJ1RECQLNOTUMP2RX7POLB | |
| SCHEMBL30445299 | 0.85 | KCNJ1 (0.49) | KCNJ1NOTUMP2RX7L3MBTL1IRAK4 | |
| SCHEMBL20168069 | 0.85 | KCNJ1 (0.49) | KCNJ1NOTUMP2RX7L3MBTL1IRAK4 | |
| SCHEMBL30445081 | 0.81 | KCNJ1 (0.48) | KCNJ1NOTUMP2RX7MAPK1 | |
| SCHEMBL20575090 | 0.81 | KCNJ1 (0.48) | KCNJ1NOTUMP2RX7MAPK1 | |
| SCHEMBL20168469 | 0.80 | RECQL (0.48) | KCNJ1RECQLP2RX7POLBTSHR | |
| SCHEMBL30444334 | 0.80 | RECQL (0.48) | KCNJ1RECQLP2RX7POLBTSHR | |
| SCHEMBL2592972 | 0.78 | RECQL (0.61) | RECQLPOLBTSHRMAPK1 | |
| SCHEMBL20176988 | 0.76 | RECQL (0.47) | KCNJ1RECQLP2RX7POLBTSHR | |
| SCHEMBL30445572 | 0.76 | RECQL (0.47) | KCNJ1RECQLP2RX7POLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110139862-B | Substituted bicyclic heterocyclic derivatives useful as ROMK channel inhibitors | 百时美施贵宝公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-110678463-B | Substituted nitrogen-containing compounds | 百时美施贵宝公司 | 2023-06-06 | — | — | CN | disclosed |