Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20168547 | 1.00 | KDM4E (0.45) | KDM4EALDH1A1HSD17B10MAPTKCNJ1 | |
| SCHEMBL24135356 | 0.79 | KCNJ1 (0.42) | KDM4EALDH1A1MAPTKCNJ1HPGD | |
| SCHEMBL30445295 | 0.78 | TP53 (0.50) | KDM4EALDH1A1HSD17B10MAPTKCNJ1 | |
| SCHEMBL20575495 | 0.78 | TP53 (0.50) | KDM4EALDH1A1HSD17B10MAPTKCNJ1 | |
| SCHEMBL30445143 | 0.75 | KCNJ1 (0.48) | KDM4EALDH1A1KCNJ1HPGDL3MBTL1 | |
| SCHEMBL20168092 | 0.75 | KCNJ1 (0.48) | KDM4EALDH1A1KCNJ1HPGDL3MBTL1 | |
| SCHEMBL15758038 | 0.74 | KDM4E (0.48) | KDM4EALDH1A1HSD17B10MAPTHPGD | |
| SCHEMBL30445067 | 0.73 | KCNJ1 (0.42) | KDM4EALDH1A1KCNJ1HPGDL3MBTL1 | |
| SCHEMBL20168321 | 0.73 | KCNJ1 (0.42) | KDM4EALDH1A1KCNJ1HPGDL3MBTL1 | |
| SCHEMBL24135382 | 0.70 | KCNJ1 (0.40) | KDM4EALDH1A1KCNJ1HPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110139862-B | Substituted bicyclic heterocyclic derivatives useful as ROMK channel inhibitors | 百时美施贵宝公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-110678463-B | Substituted nitrogen-containing compounds | 百时美施贵宝公司 | 2023-06-06 | — | — | CN | disclosed |