Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | PYGL | P06737 | 1/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22206894 | 1.00 | KCNH2 (0.50) | KCNH2PYGLPDE2APSEN1PSEN2 | |
| SCHEMBL22206866 | 1.00 | KCNH2 (0.50) | KCNH2PYGLPDE2APSEN1PSEN2 | |
| SCHEMBL30446626 | 1.00 | KCNH2 (0.50) | KCNH2PYGLPDE2APSEN1PSEN2 | |
| SCHEMBL3195180 | 1.00 | KCNH2 (0.50) | KCNH2PYGLPDE2APSEN1PSEN2 | |
| SCHEMBL30446289 | 1.00 | KCNH2 (0.50) | KCNH2PYGLPDE2APSEN1PSEN2 | |
| SCHEMBL24370395 | 0.87 | KCNH2 (0.52) | KCNH2PYGLPDE2AMDM2GRIN2B | |
| SCHEMBL20943342 | 0.87 | PSEN1 (0.43) | KCNH2PYGLPSEN1PSEN2APH1B | |
| SCHEMBL20943341 | 0.87 | PSEN1 (0.43) | KCNH2PYGLPSEN1PSEN2APH1B | |
| SCHEMBL22618975 | 0.87 | PSEN1 (0.43) | KCNH2PYGLPSEN1PSEN2APH1B | |
| SCHEMBL30446762 | 0.87 | PSEN1 (0.43) | KCNH2PYGLPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111434671-B | Liver-specific AMPK agonist and preparation method and application thereof | 凯思凯迪（上海）医药科技有限公司 | 2023-07-11 | — | — | CN | disclosed |