Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28410341 | 0.82 | MEN1 (0.61) | GAAMEN1TSHRKMT2A | |
| SCHEMBL11560101 | 0.81 | GAA (0.62) | GAACYP2D6ALDH1A1CYP3A4MEN1 | |
| SCHEMBL19743237 | 0.81 | KCNH2 (0.60) | ALDH1A1KCNH2MEN1KMT2A | |
| SCHEMBL22470297 | 0.80 | MEN1 (0.62) | GAAMEN1TSHRKMT2A | |
| SCHEMBL25253582 | 0.80 | SMN1; SMN2 (0.71) | CYP2D6ALDH1A1CYP3A4MEN1KMT2A | |
| SCHEMBL518686 | 0.80 | NPC1 (0.71) | GAAALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL5501378 | 0.80 | KMT2A (0.57) | ALDH1A1KCNH2MEN1TSHRKMT2A | |
| SCHEMBL12803104 | 0.79 | GAA (0.63) | GAAMEN1TSHRKMT2A | |
| Hydrochloric Acid SCHEMBL5712502 | 0.79 | NPC1 (0.70) | GAAALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL2262431 | 0.77 | CHRM4 (0.65) | CYP2D6ALDH1A1MEN1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4178963-A1 | 5-[5-(PIPERIDIN-4-YL)THIENO[3,2-C]PYRAZOL-2-YL]INDAZOLE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS FOR SPLICING NUCLEIC ACIDS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Remix Therapeutics Inc. (US) | 2023-05-17 | — | — | EP | disclosed |