SCHEMBL30448317 — predicted protein targets

Predicted protein targets (top 14)

	gene	UniProt	supporting neighbours	confidence
▸	KDR	P35968	18/20	0.45

▸	EGFR	P00533	1/20	0.45

▸	AURKA	O14965	2/20	0.42

▸	MET	P08581	2/20	0.42

▸	TEK	Q02763	2/20	0.42

▸	AURKB	Q96GD4	2/20	0.42

▸	CSF1R	P07333	1/20	0.39

▸	PDGFRA	P16234	3/20	0.39

▸	KIT	P10721	1/20	0.39

▸	FGFR2	P21802	1/20	0.39

▸	AXL	P30530	1/20	0.39

▸	BRAF	P15056	1/20	0.38

▸	PDE4A	P27815	1/20	0.38

▸	PDE4D	Q08499	1/20	0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL28466219	1.00	KDR (0.45)	KDREGFRAURKAMETTEK
SCHEMBL28471178	0.88	KDR (0.48)	KDREGFRAURKAMETTEK
SCHEMBL30448547	0.88	KDR (0.48)	KDREGFRAURKAMETTEK
SCHEMBL30448826	0.86	KDR (0.40)	KDREGFRMETCSF1RPDGFRA
SCHEMBL28464541	0.86	KDR (0.40)	KDREGFRMETCSF1RPDGFRA
SCHEMBL28474019	0.84	KDR (0.65)	KDREGFRAURKAMETTEK
SCHEMBL30447669	0.84	KDR (0.65)	KDREGFRAURKAMETTEK
SCHEMBL30447731	0.78	KDR (0.62)	KDRAURKAMETTEKAURKB
SCHEMBL28473963	0.78	KDR (0.62)	KDRAURKAMETTEKAURKB
SCHEMBL30448235	0.76	KDR (0.44)	KDREGFRMETPDGFRABRAF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
CN-111825605-B	Aryl ketone amide compound and preparation method and application thereof	中国科学院上海药物研究所	2023-03-31	—	—	CN	disclosed