Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB4 | P54760 | 14/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.33 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | TEK | Q02763 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | PRKCB | P05771 | 1/20 | 0.33 |
| ▸ | INSR | P06213 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | LYN | P07948 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19922742 | 1.00 | EPHB4 (0.35) | EPHB4KDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL19934120 | 0.93 | KDM4E (0.36) | EPHB4KDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL19922747 | 0.90 | EPHB4 (0.30) | EPHB4 | |
| SCHEMBL19922749 | 0.89 | EPHB4 (0.37) | EPHB4KDRTEKABL1EGFR | |
| SCHEMBL19922748 | 0.88 | PARP1 (0.33) | EPHB4 | |
| SCHEMBL19922673 | 0.86 | EPHB4 (0.34) | EPHB4KDRTEK | |
| SCHEMBL30450535 | 0.86 | EPHB4 (0.34) | EPHB4KDRTEK | |
| SCHEMBL19922990 | 0.85 | AR (0.33) | EPHB4KDRTEKABL1EGFR | |
| SCHEMBL19922954 | 0.85 | GRIA1 (0.35) | EPHB4KDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL19922806 | 0.85 | EPHB4 (0.32) | EPHB4KDRTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4472620-A1 | A SOLUBLE GUANYLAT CYCLASE ACTIVATOR FOR TREATING CHRONIC VASCULAR DYSFUNCTION | Charité - Universitätsmedizin Berlin (DE) | 2024-12-11 | — | — | EP | disclosed |
| CN-117105939-A | Fused bicyclic sGC stimulators | 帝善多制药公司 | 2023-11-24 | — | — | CN | disclosed |
| WO-2023148203-A1 | A SOLUBLE GUANYLAT CYCLASE ACTIVATOR FOR TREATING CHRONIC VASCULAR DYSFUNCTION | CHARITÉ - UNIVERSITÄTSMEDIZIN BERLIN (DE) | 2023-08-10 | — | — | WO | disclosed |
| CN-109790167-B | SGC stimulators | 塞科里昂医疗股份有限公司 | 2023-06-20 | — | — | CN | disclosed |