Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 18/20 | 0.66 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | INSR | P06213 | 2/20 | 0.45 |
| ▸ | IGF1R | P08069 | 2/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3510229 | 1.00 | NTRK1 (0.66) | NTRK1PDPK1JAK2INSRIGF1R | |
| SCHEMBL29415511 | 0.88 | NTRK1 (0.52) | NTRK1PDPK1JAK2AURKB | |
| SCHEMBL3512493 | 0.88 | NTRK1 (0.52) | NTRK1PDPK1JAK2AURKB | |
| SCHEMBL29415512 | 0.88 | NTRK1 (0.52) | NTRK1PDPK1JAK2AURKB | |
| SCHEMBL23901370 | 0.83 | NTRK1 (0.64) | NTRK1INSRIGF1RALKAURKA | |
| SCHEMBL3512392 | 0.81 | JAK2 (0.58) | NTRK1PDPK1JAK2AURKAAURKB | |
| SCHEMBL3513208 | 0.80 | SGK1 (0.45) | NTRK1PDPK1JAK2INSRALK | |
| SCHEMBL14177539 | 0.78 | JAK2 (0.55) | NTRK1PDPK1JAK2AURKAAURKB | |
| SCHEMBL3514510 | 0.77 | NTRK1 (0.42) | NTRK1PDPK1JAK2INSRALK | |
| SCHEMBL1336197 | 0.77 | NTRK1 (0.60) | NTRK1PDPK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115916771-B | Multi-target antitumor compound and preparation method and application thereof | 浙江华海药业股份有限公司 | 2025-04-01 | — | — | CN | disclosed |
| CN-113801062-B | Preparation method of 3-amino-5- (3, 5-difluorobenzyl) -1H-indazole | 沈阳药科大学 | 2023-05-26 | — | — | CN | disclosed |
| CN-113801062-B | Preparation method of 3-amino-5- (3, 5-difluorobenzyl) -1H-indazole | 沈阳药科大学 | 2023-05-26 | — | — | CN | disclosed |
| CN-113801062-B | Preparation method of 3-amino-5- (3, 5-difluorobenzyl) -1H-indazole | 沈阳药科大学 | 2023-05-26 | — | — | CN | disclosed |