Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 3/20 | 0.61 |
| ▸ | JAK3 | P52333 | 2/20 | 0.61 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.60 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 3/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 3/20 | 0.47 |
| ▸ | SUV39H2 | Q9H5I1 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29017689 | 1.00 | BTK (0.61) | BTKJAK3MAP4K4PDE10AAURKA | |
| SCHEMBL27424358 | 1.00 | BTK (0.61) | BTKJAK3MAP4K4PDE10AAURKA | |
| SCHEMBL31200683 | 1.00 | BTK (0.61) | BTKJAK3MAP4K4PDE10AAURKA | |
| SCHEMBL17296049 | 0.93 | MEN1 (0.55) | BTKJAK3MAP4K4PDE10AMEN1 | |
| SCHEMBL17296051 | 0.93 | MEN1 (0.55) | BTKJAK3MAP4K4PDE10AMEN1 | |
| SCHEMBL31271096 | 0.88 | MAP4K4 (0.64) | BTKJAK3MAP4K4PDE10AAURKA | |
| SCHEMBL12025085 | 0.88 | MAP4K4 (0.59) | BTKJAK3MAP4K4PDE10AAURKA | |
| SCHEMBL13390777 | 0.88 | MAP4K4 (0.59) | BTKJAK3MAP4K4PDE10AAURKA | |
| SCHEMBL31271299 | 0.88 | MAP4K4 (0.59) | BTKJAK3MAP4K4PDE10AAURKA | |
| SCHEMBL24108813 | 0.86 | MEN1 (0.60) | BTKJAK3PDE10AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114478478-B | N- (1- (6- (substituted phenyl) pyridazin-3-yl) piperidin-3-yl) amine/amide derivatives and process for preparing the same | 厦门大学 | 2023-06-13 | — | — | CN | disclosed |