Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG | P00747 | 1/20 | 0.56 |
| ▸ | F12 | P00748 | 1/20 | 0.56 |
| ▸ | F11 | P03951 | 1/20 | 0.56 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.56 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.56 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.56 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.56 |
| ▸ | MGLL | Q99685 | 2/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 7/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24252733 | 1.00 | PLG (0.56) | PLGF12F11KLKB1PRSS1 | |
| SCHEMBL26771032 | 0.90 | PLG (0.45) | PLGF12F11KLKB1PRSS1 | |
| SCHEMBL30453230 | 0.84 | PLG (0.39) | PLGF12F11KLKB1PRSS1 | |
| SCHEMBL24252359 | 0.84 | PLG (0.39) | PLGF12F11KLKB1PRSS1 | |
| SCHEMBL24252369 | 0.83 | PLG (0.42) | PLGF12F11KLKB1PRSS1 | |
| SCHEMBL24252257 | 0.83 | PLG (0.52) | PLGF12F11KLKB1PRSS1 | |
| Hydrochloric Acid SCHEMBL30467690 | 0.82 | PLG (0.51) | PLGF12F11KLKB1PRSS1 | |
| SCHEMBL24252263 | 0.81 | MAP4K4 (0.37) | PLGF12F11KLKB1PRSS1 | |
| SCHEMBL30467557 | 0.80 | PLG (0.36) | PLGF12F11KLKB1PRSS1 | |
| SCHEMBL24252711 | 0.80 | PLG (0.36) | PLGF12F11KLKB1PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116947903-A | Inhibitors of complement factors and uses thereof | 安尼艾克松股份有限公司 | 2023-10-27 | — | — | CN | disclosed |
| CN-116261564-A | Inhibitors of complement factors and uses thereof | 安尼艾克松股份有限公司 | 2023-06-13 | — | — | CN | disclosed |
| EP-4185592-A1 | INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF | Annexon, Inc. (US) | 2023-05-31 | — | — | EP | disclosed |